ceesdekker.net Secrets

Making use of solitary-molecule optical and AFM imaging and power-spectroscopy methods, we seek to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis pursuits include things like:

Human Rad51 filaments on double- and single-stranded DNA: correlating standard and irregular sorts with recombination operate.

Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins

Since 2000, Dekker has shifted the principle focus of his perform toward biophysics where he reports the Attributes of single biomolecules and cells using the equipment of nanotechnology. This modification of field was driven by his fascination for your outstanding operating of Organic molecular buildings, as well as through the prolonged-time period standpoint that many fascinating discoveries might be predicted With this industry.[five] Current lines of study in his biophysics group are within the areas of:[six]

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Our analysis ranges from your biophysics of DNA to synthetic cells and past. Make sure you have a look beneath at the spectrum of our current projects.

A lot of linked developments adopted, wherever our team recognized unique transistor variants for instance one-electron transistors at place temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled many transistors into smaller evidence-of-theory electronic circuits.

Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is shown in gray, the rim of the pore is highlighted in purple, along with a 3D rendering with the motion on the DNA rod is displayed.

Let's say, instead of employing standard major-down silicon electronics, transistors may be built from The underside up using solitary organic molecules as being the switching components? This concept, which became The idea of today’s discipline of molecular electronics, first emerged while in the nineteen seventies.

It was in the course of this period that Dekker completed exploration on magnetic spin devices and on sounds in superconductors and semiconductors.

Testing pseudotopological and nontopological types for SMC-pushed DNA ceesdekker loop extrusion towards roadblock-traversal experiments

Character Physics thanks the nameless reviewers for their contribution into the peer critique of this do the job.

Such as, we consider the nucleopore sophisticated, a gateway in between the mobile nucleus plus the cytoplasm. This is an extremely complex system and for that reason tough to research inside of a mobile, so we use biomimetics. We reconstruct holes and after that insert unique things in the nucleopore complex to check transport as a result of it at The only-molecule level.’

‘I'm pushed by speculate and thoughts. On a material level I find answers in physics, but I knowledge my deepest joy with God. That faith also drives my science And the way I handle men and women.